A person whose desire rests on you, you preserve in perfect peace, because he trusts in you. Isaiah 26:3
What does your heart desire? Money, fame, relationships, a job title, drugs, sex, comfort etc.
You are created to desire fellowship with your Maker. However we are trained by the world to desire the things of the world, things we may see on tv or movies.
Seeking after the things of the world will only lead to unrest. You can never be satisfied because you weren't created to get your satisfaction from those things.
Turn to Christ. Desire him. He alone can bring satisfaction. He alone can bring the unexplainable peace that you are looking for.